HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Eric Oldfield Selected Research

Therapeutics

12/2019Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells.
11/2014A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
5/2014Squalene synthase as a target for Chagas disease therapeutics.
12/2013Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.
3/2010Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.
2/2006Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
1/2006Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.
5/2005Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
1/2004Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
7/2003A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.
For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


Eric Oldfield Research Topics

Disease

20Bone Resorption
12/2019 - 07/2002
16Neoplasms (Cancer)
09/2023 - 09/2004
10Infections
09/2023 - 05/2003
8Chagas Disease (American Trypanosomiasis)
05/2014 - 03/2004
6Malaria
01/2018 - 09/2010
5Tuberculosis (Tuberculoses)
10/2016 - 02/2014
3Osteoporosis
01/2018 - 03/2010
3African Trypanosomiasis (Nagana)
01/2006 - 10/2004
2Toxoplasmosis
10/2022 - 10/2007
2Fibrosis (Cirrhosis)
01/2017 - 01/2017
2Communicable Diseases (Infectious Diseases)
03/2015 - 06/2009
2Cutaneous Leishmaniasis
03/2014 - 07/2002
2Polyps
12/2004 - 10/2004
1Mycoses (Diseases, Fungus)
07/2022
1Coronavirus Infections
10/2020
1Respiratory Tract Infections (Respiratory Tract Infection)
10/2020
1Severe Acute Respiratory Syndrome
10/2020
1Plague (Bubonic Plague)
10/2020
1COVID-19
10/2020
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2019
1Starvation
01/2019
1Alzheimer Disease (Alzheimer's Disease)
11/2018
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
07/2017
1Sarcoma (Soft Tissue Sarcoma)
07/2017
1Glioblastoma (Glioblastoma Multiforme)
12/2015
1Breast Neoplasms (Breast Cancer)
07/2015
1Adenocarcinoma of Lung
11/2014
1Neglected Diseases
05/2014
1Cardiac Arrhythmias (Arrythmia)
01/2014
1Leishmaniasis
01/2014

Drug/Important Bio-Agent (IBA)

26Diphosphonates (Bisphosphonates)IBA
10/2022 - 07/2002
9EnzymesIBA
01/2018 - 07/2002
6Terpenes (Terpenoids)IBA
04/2015 - 03/2004
5farnesyl pyrophosphate (farnesyl diphosphate)IBA
12/2019 - 07/2002
5Zoledronic Acid (Zometa)FDA Link
12/2019 - 03/2012
5Farnesyltranstransferase (Farnesyltransferase)IBA
01/2018 - 10/2007
5GeranyltranstransferaseIBA
03/2015 - 10/2004
5Risedronic Acid (Actonel)FDA LinkGeneric
03/2012 - 03/2002
4NitrogenIBA
07/2010 - 05/2003
3Diphosphates (Pyrophosphates)IBA
01/2019 - 12/2008
3Proteins (Proteins, Gene)FDA Link
04/2014 - 04/2009
3prenylIBA
03/2012 - 12/2008
3Antiparasitic Agents (Antiparasitics)IBA
09/2010 - 07/2003
3diphosphoric acid (pyrophosphoric acid)IBA
04/2007 - 10/2004
3Pamidronate (Aredia)FDA LinkGeneric
01/2004 - 07/2002
2ButyrophilinsIBA
09/2023 - 01/2019
2Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA
07/2022 - 05/2014
2AntigensIBA
11/2018 - 01/2004
2LigandsIBA
07/2017 - 12/2010
2Adenosine (Adenocard)FDA LinkGeneric
12/2015 - 04/2015
2dipalmitoylphosphatidylserineIBA
06/2015 - 02/2014
2Virulence Factors (Pathogenicity Factors)IBA
06/2015 - 04/2015
2SterolsIBA
05/2014 - 09/2010
2Amiodarone (Amiodarona)FDA LinkGeneric
01/2014 - 02/2006
2CholesterolIBA
09/2010 - 03/2008
2HexokinaseIBA
04/2007 - 01/2006
2PolyphosphatesIBA
12/2004 - 10/2004
2Phosphorus (Red Phosphorus)IBA
09/2004 - 01/2004
1Ubiquinone Q1IBA
10/2022
1trans-hexaprenyltranstransferaseIBA
10/2022
1VaccinesIBA
10/2020
1salvinIBA
12/2019
1DiterpenesIBA
12/2019
11-tuberculosinyladenosineIBA
01/2019
1celastrolIBA
01/2019
14,6-dinitro-o-cresol (DNOC)IBA
01/2019
1Mixed Function Oxygenases (Monooxygenases)IBA
01/2019
1SiderophoresIBA
01/2019
1IronIBA
01/2019
1Mevalonic Acid (Mevalonate)IBA
11/2018
1Vaccine AdjuvantsIBA
11/2018
1AntibodiesIBA
11/2018
1Chalcone (Benzalacetophenone)IBA
11/2018
1Choline (Choline Chloride)IBA
11/2018
1coumarinIBA
11/2018
1VancomycinFDA LinkGeneric
03/2018
1QuinonesIBA
01/2018
1ErbB Receptors (EGF Receptor)IBA
07/2017
1Amine Oxidase (Copper-Containing)IBA
01/2017
1ElastinIBA
01/2017
1Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
01/2017
1CollagenIBA
01/2017
1DiaminesIBA
10/2016
1EthaneIBA
10/2016
1Membrane Proteins (Integral Membrane Proteins)IBA
12/2015
1Biomarkers (Surrogate Marker)IBA
04/2015
1Monomeric GTP-Binding ProteinsIBA
11/2014
1Sirolimus (Rapamycin)FDA Link
11/2014
1Guanine NucleotidesIBA
11/2014
1TOR Serine-Threonine KinasesIBA
11/2014
1Carrier Proteins (Binding Protein)IBA
11/2014
1Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
11/2014
1Oxidoreductases (Dehydrogenase)IBA
06/2014
1decaprenyl pyrophosphate synthetaseIBA
02/2014
1DronedaroneFDA Link
01/2014
1Benzofurans (Coumarones)IBA
01/2014

Therapy/Procedure

12Therapeutics
12/2019 - 07/2002
5Drug Therapy (Chemotherapy)
10/2022 - 09/2004
4Immunotherapy
11/2018 - 03/2006
1Personal Protective Equipment
10/2020